Prediction of Protein Binding Regions in Disordered Proteins

 

ANCHOR
Theory
How to use
IUPred
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Many disordered proteins function via binding to a structured partner and undergo a disorder-to-order transition. In order to predict disordered binding regions, ANCHOR seeks to identify segments that reside in disordered regions, cannot form enough favorable intrachain interactions to fold on their own and are likely to gain stabilizing energy by interacting with a globular protein partner. The approach relies on the pairwise energy estimation approach that is the basis for IUPred, a general disorder prediction method.

To run ANCHOR on multiple sequences you can use this site.
 
   

Protein Sequence
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Motifs
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Output type: raw data only
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References:

Bálint Mészáros, István Simon and Zsuzsanna Dosztányi (2009)
Prediction of Protein Binding Regions in Disordered Proteins
PLoS Comput Biol 5(5): e1000376. doi:10.1371/journal.pcbi.1000376

Zsuzsanna Dosztányi, Bálint Mészáros and István Simon (2009)
ANCHOR: web server for predicting protein binding regions in disordered proteins
Bioinformatics 25(20): 2745-2746.